Clinical and morphological features of localized laryngeal amyloidosis

Introduction. Amyloidosis is a disease characterized by extracellular deposition of insoluble fibrils composed an abnormal protein, amyloid. This protein builds up in various tissues and organs interferes with their function leading to atrophy sclerosis. usually systemic disease. However, there are case reports localized amyloidosis. Localized laryngeal amyloidosis rare condition accounting for approximately 15% The aim the research was describe morphological features Materials methods. We analyzed clinical findings, biopsy, surgical specimens 6 patients Amyloid deposits were detected tissue sections Congo red stain polarized light microscopy. performed immunohistochemical analysis monoclonal polyclonal antibodies detect different amyloid types. Results. Laryngeal diagnosed 4 male 2 female aged from 44 62 (the mean age 54 years). found interstitial spaces tumor-like masses; light, showed bright apple-green birefringence. Inflammatory cell infiltrate multinucleated giant cells visualized most cases. Based on typing results, had AL-kappa AL-lambda recurrence reported Conclusion. In head neck area, larynx common site affected prevailed our study, them being men. view high rates, long-term follow-up needed after deposit excision. Keywords: amyloidosis, larynx, amyloidoma, immunohistochemistry